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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE289898 Escape from X inactivation is directly modulated by Xist non-coding RNA [Astrocytes] December 9, 2025Contributors : Edith Heard ; Agnese Loda ; Antonia Hauth ; Jasper PantenSeries Type : Expression profiling by high throughput sequencingOrganism : MusX-chromosome inactivation (XCI) silences one copy of the X-chromosome in female cells, but a number of genes escapes XCI. We asked whether increased levels of Xist RNA, the molecular actor driving X-inactivatio […]
- GSE288403 Olfr2 deficiency protects from abdominal aortic aneurysm December 9, 2025Contributors : Schelemei Patrik ; Winkels HolgerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOlfactory receptor 2 is a G-protein coupled receptor expressed on vascular macrophages. Activation by its ligand octanal in conjuction with a toll like receptor 4 stimulus induces the NLRP3 inflammasome with subsequent IL-1al […]
- GSE312800 To study the expression profile change after treatment of ZN-c5 and 4-OH Tamaxifen in MCF-7 cells December 9, 2025Contributors : Jianhui Ma ; Fernando Donate ; Ahmed SamatarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndocrine therapy has proven to be beneficial for patients with estrogen receptor (ER) positive, HER2 negative (ER+/HER2-) breast cancer; however, de novo or acquired resistance remains a major clinical challenge. […]
- GSE289900 Escape from X inactivation is directly modulated by Xist non-coding RNA [E8.5] December 9, 2025Contributors : Edith Heard ; Agnese Loda ; Emma Kneuss ; Jasper PantenSeries Type : Expression profiling by high throughput sequencingOrganism : MusX-chromosome inactivation silences one copy of the X-chromosome in female cells, but a number of genes escapes XCI. We asked whether increased levels of Xist RNA, the molecular actor driving X-inactivation, impac […]
- GSE260483 Escape from X inactivation is directly modulated by Xist non-coding RNA [methylation] December 9, 2025Contributors : Edith Heard ; Agnese Loda ; Antonia Hauth ; Jasper PantenSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus ; Mus musculusX-chromosome inactivation silences one copy of the X-chromosome in female cells, but a number of genes escapes this inactivation. We asked whether increased levels of Xist RNA, the molecular act […]
- GSE259396 Escape from X inactivation is directly modulated by Xist non-coding RNA [in vivo] December 9, 2025Contributors : Edith Heard ; Agnese Loda ; Emma Kneuss ; Jasper PantenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus ; Mus musculusX-chromosome inactivation silences one copy of the X-chromosome in female cells, but a number of genes escapes XCI. We asked whether increased levels of Xist RNA, the molecular actor driving X-inac […]
- GSE312546 Abnormal shear stress induces ferroptosis in endothelial cells via KLF6 downregulation December 9, 2025Contributors : Jingang Cui ; Zhiyu Fan ; Suoqi Ding ; Jiazhen Zhang ; Huihong Shen ; Syeda Armana Zaidi ; Yongsheng DingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensStable laminar flow maintains vascular tone regulation, while abnormal blood flow, such as disturbed flow or extreme shear stress, causes endothelial dys […]
- GSE270919 Ketogenic regulation of histone modification by CDK4 promotes leukemogenesis [RNA-seq] December 9, 2025Contributors : Jin Xu ; Guoliang Qing ; Hudan LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile ketogenic nutrition shows promise as an adjunct to conventional cancer therapies, its efficacy varies depending on the type of cancer and its specific metabolic characteristics. How ketone bodies affect tumorigenesis a […]
- GSE312636 Large scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell cycle and DNA repair regulation December 9, 2025Contributors : Benjamin Herken ; Garrett Wong ; Anna Makiniemi ; Emma Lundberg ; Thomas Norman ; Luke GilbertSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCells integrate exogenous and endogenous signals to grow, repair or die. This is likely achieved through dynamic functional associations between genes but m […]
- GSE312581 Novel SLCO2B1 mRNA isoform acts as a noncoding RNA and drives cancer progression through FMR1-mediated protein biosynthesis December 9, 2025Contributors : Wenying Qiu ; Xianghuo HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe eukaryotic 5’ untranslated region (5’ UTR) canonically influences mRNA translation efficiency. However, the role of the 5’ UTR structure in blocking mRNA translation and turning a coding RNA into a noncoding RNA rem […]
- GSE312662 The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction December 9, 2025Contributors : Dominic A Ritacco ; Hamna Shahnawaz ; Antonia Oduguwa ; Jacob Hawk ; Brianna Vizcaino ; Donna Farber ; Ryan G GaudetSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLysosomal damage is an endogenous danger signal to the cell, but its significance for innate immunity and how specific signaling pathways are […]
- GSE312673 Spatiotemporal dysregulation of plasma fibrinogen synthesis unveils hepatic initiating role in MS and EAE pathogenesis December 9, 2025Contributors : Jiaji Lin ; Xinyan Han ; Chuanping Zhao ; Yanan Bai ; Weitai He ; Xiaoli Liu ; Jun GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibrinogen, Multiple sclerosis, Liver, EAE, Neutrophils
- GSE312686 Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1 December 9, 2025Contributors : Marisa A Bickel ; David M Sherry ; Elizabeth C Bullen ; Michaela L Vance ; Ken L Jones ; Eric W Howard ; Shannon M ConleySeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusObjective: Vascular smooth muscle cell (VSMC) phenotypic switching is critical for normal vessel formation, vascular stability, and […]
- GSE286121 Resident CD49a⁺CD103⁺NKG2C⁺ NK Cells Restrict HIV Infection in Human Lymphoid Tissue Explants December 9, 2025Contributors : María José Buzón ; David Perea ; Alba González ; Irene MotaSeries Type : Expression profiling by high throughput sequencingOrganism : HIV-1 group M ; Homo sapiensNatural killer (NK) cells are pivotal effectors in antiviral immunity, yet their tissue-specific roles during acute HIV infection remain poorly defined. Using an ex vivo human tonsill […]
- GSE312543 P-bodies act as sites for dynamic RNA processing December 9, 2025Contributors : Matthew W Feng ; Simon J Hubbard ; Mark P Ashe ; Chris M GrantSeries Type : OtherOrganism : Saccharomyces cerevisiaeProcessing bodies (PBs) are cytoplasmic granules that function in the cellular response to stress conditions by regulating mRNA metabolism. They are thought to act as sites where non-translating mRNAs are localised to undergo deg […]