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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE252086 Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction December 1, 2025Contributors : Andrew L Koenig ; Farid F Kadyrov ; Junedh M Amrute ; Steven Yang ; Carla J Weinheimer ; Jessica M Nigro ; Attila Kovacs ; Gabriella Smith ; Kory J LavineSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation contributes to the pathogenesis of cardiac disease and represents a viable therapeutic targ […]
- GSE272422 Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation December 1, 2025Contributors : Huanhuan Liu ; Anupama Binoy ; Siqi Ren ; Thomas C Martino ; Anna E Miller ; Craig R Willis ; Shivakumar R Veerabhadraiah ; Abhijit Sukul ; Martin K Lotz ; Rachel E Miller ; Anne-Marie Malfait ; Michael J Jurynec ; Shouan ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChondrocyte metabolic dysfunction […]
- GSE266936 Deletion of SWI/SNF ATPase activity in hepatocytes of adult liver disrupts circadian gene expression and central liver functions [ATACseq] December 1, 2025Contributors : Nicolaj I Toft ; Victor E Goitea ; Lars GrøntvedSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe circadian rhythm in the murine liver governs the activity of numerous enhancers which in turn coordinates diurnal gene expression. This process is controlled by oscillating activities of speci […]
- GSE281468 Regulation of heterochromatin formation and tumor suppression in leukemia by IKAROS, HDAC1 and EZH2 [Molt4_RNA] December 1, 2025Contributors : Sinisa Dovat ; Yali Ding ; Bing HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe IKZF1 gene encodes IKAROS – a DNA binding protein that acts as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). IKAROS can act as a transcriptional repressor via chromatin remodeling, however the mechan […]
- GSE277428 NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma December 1, 2025Contributors : Sojeong Kim ; Jeong-Eun Kwak ; June-Young Koh ; Ji Eun Le ; Hye Won Kook ; Minchae Kim ; Haerim Chung ; Yu Ri Kim ; Soo Jeong Kim ; Jin Seok Kim ; June-Won Cheong ; Min Goo Lee ; Hoyoung Lee ; Su-Hyung Park ; Eui-Cheol Shin ; Saeam Shin ; Sun Ock Yoon ; Kihyun Kim ; Il-Kyu Choi ; Jeong Seok Lee ; Hyunsoo ChoSeries Type : Expression profiling b […]
- GSE203198 Integrated control of mitochondrial dynamics and cancer cell stemness by σ1 receptor December 1, 2025Contributors : Giada Sandrini ; Gianluca Civenni ; Carlo V CatapanoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor cells endowed with cardinal stem cell properties are pervasively present in human cancers. Cancer stem cells (CSCs) play an essential role in metastasis, treatment resistance, and disease recurrence. […]
- GSE283722 SGLT2 Inhibitor Empagliflozin Enhances Metabolic Efficiency and Ameliorates Left Ventricular Hypertrophy in Myosin R403Q Mutant Hypertrophic Cardiomyopathy Mice December 1, 2025Contributors : Tomas Baka ; Ivan LuptakSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and impaired metabolic efficiency. This study investigates the therapeutic potenti […]
- GSE311699 A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure [Micro-C] December 1, 2025Contributors : Sonja Lazarevic ; Carlos Perez-Cervantes ; Alexander J Ruthenburg ; Ivan P MoskowitzSeries Type : OtherOrganism : Mus musculusAtrial fibrillation (AF) and heart failure (HF) frequently co-occur and exacerbate each other's morbidity, yet the underlying molecular mechanisms remain incompletely understood. Here, we compared atrial gene regul […]
- GSE311668 Transcriptomic profiling of Adcy7-knockout bone marrow-derived macrophages December 1, 2025Contributors : Guofang Xia ; Congfeng XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMyocardial ischemia/reperfusion (I/R) injury remarkably thwarts the therapeutic efficiency of percutaneous coronary intervention for myocardial ischemia disorders, and cardiac macrophages have been shown to play critical roles during […]
- GSE311743 Modeling Liver Cancer Molecular and Histological Features by CRISPR Editing of Primary Porcine Hepatocytes December 1, 2025Contributors : Lobna Elkhadragy ; Olayinka G David ; Caitlyn C Castillo ; Luke N Redlon ; Luke R Jordan ; Kyle M Schachtschneider ; Ron C GabaSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaPreclinical models are essential for advancing therapeutic strategies in hepatocellular carcinoma (HCC), an aggressive disease with p […]
- GSE311705 Uterine epithelial ERα regulates preimplantation uterine luminal epithelial (LE) and uterine mRNAs December 1, 2025Contributors : Jonathan M Hancock ; Tong Zhou ; Yuehuan Li ; Taylor E Martin ; Moya Zhang ; Xiaoqin YeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUterine epithelial estrogen receptor α (ERα) deficiency in epiERα-/- (Esr1f/-Wnt7aCre/+) mice leads to dysregulated environment of uterine lumen, which is lined by uterine […]
- GSE311749 Upper Airway Gene Expression in Hospitalized Children with Rhinovirus-induced Respiratory Illnesses December 1, 2025Contributors : Jordan E Kreger ; Alex L Sliwicki ; Saly N Essoh ; Yiran Li ; Chaandini Jayachandran ; Jessica A Czapla ; Toby C Lewis ; Erin M Kirkham ; Rodney J Vergotine ; Antonia P Popova ; Heidi R Flori ; Marc B HershensonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we collected nasal swabs from in […]
- GSE311806 Dietary Salt Impairs Circadian Physiological Metabolic Adaptations in Salt-Sensitive Hypertension December 1, 2025Contributor : Alexander StaruschenkoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe body's circadian rhythm is coordinated by a central hypothalamic and peripheral molecular clocks, which involve clock proteins (PER, CRY, CLOCK, and BMAL1). Our recent study demonstrated that deletion of Per1 in Dahl salt-s […]
- GSE311807 Human microglia differentially respond to ß-amyloid, tau, and combined Alzheimer's disease pathologies in vivo [scRNA-Seq] December 1, 2025Contributors : Morgan Coburn ; Ghazaleh Eskandari-Sedighi ; Jonathan Hasselmann ; Whitney England ; Mathew Blurton-JonesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent studies have identified important species-dependent differences in the response of microglia to beta-amyloid pathology. Yet, whether human microgl […]
- GSE249046 PD-1+TCF-1+ stem-like CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation December 1, 2025Contributors : Julia Busselaar ; Douwe M Bosma ; Mo D Staal ; Xin Lei ; Yanling Xiao ; Jannie BorstSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusIn cancer and chronic infection, antigen-specific CD8+ T cells can be in a stem-like/progenitor exhausted PD-1+TCF-1+ state that progresses into terminal exhaustion. […]