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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE211298 Series-temporal transcriptome profiling of cotton reveals the response mechanism of phosphatidylinositol signaling system in the early stage of drought stress August 11, 2025Contributors : Xiaoge Wang ; Yongsheng Deng ; Liying Gao ; Fanjin Kong ; Guifang Shen ; Bing Duan ; Zongwen Wang ; Maohua Dai ; Zongfu HanSeries Type : Expression profiling by high throughput sequencingOrganism : Gossypium hirsutumTo investigate the response mechanism in the early stage of cotton to drought stress, we performed gene expression profiling anal […]
- GSE247790 Aberrant splicing exonizes C9ORF72 repeat expansion in ALS/FTD August 11, 2025Contributors : Suzhou Yang ; Denethi Wijegunawardana ; Udit Sheth ; Austin M Veire ; Juliana M Salgado ; Tanina Arab ; Manasi Agrawal ; Jeffrey Zhou ; João D Pereira ; Tania F Gendron ; Junjie U GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA nucleotide repeat expansion (NRE) in the first annotated intron of the C9 […]
- GSE228354 Induction of embryonic axes by distinct population of the Hensens's node August 11, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Gallus gallusThis SuperSeries is composed of the SubSeries listed below.
- GSE273337 Medium-chain triglycerides improve cognition and systemic metabolism in Alzheimer mice I August 11, 2025Contributors : Paule E M'Bra ; Laura K Hamilton ; Gaël Moquin-Beaudry ; Chenicka L Mangahas ; Federico Pratesi ; Anne Aumont ; Karl J FernandesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLifestyle-based interventions, including dietary modifications, can reduce dementia risk. In this regard, dietary supplementa […]
- GSE269971 The role of Spp1 in pancreatic cancer August 11, 2025Contributors : Huafu Li ; Linxiang Lan ; Axel BehrensSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA-seq analysis on Spp1 wild-type and CRISPR/Cas9-mediated Spp1 knock out pancreatic tumour organiod from Pdx1-Flp;KrasFSF-G12D;Trp53frt/frt; Vim-EGFP (KPFV) mice. We compared the transcriptome between thes […]
- GSE277816 Role of endothelial STING1 in the transcriptional response to LPS August 11, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq analysis of kidney endothelium and whole kidney from mice 15 hours after an intraperitoneal challenge with 250 micrograms of LPS per mouse.
- GSE276444 Nutrient-driven TOR signaling mediates transcriptional repression by promoting translation to regulate plant growth [ChIP-seq] August 11, 2025Contributor : Xin J HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaAs is well known, nutrition is essential for plant growth and development. Extensive research has demonstrated that the target of rapamycin (TOR) is a crucial growth regulator, receiving nutritional inputs in eukaryotic cells. Ne […]
- GSE304274 Targeting the AKT–EphA2 Axis and Cell–Cell Adhesion Enhances Anoikis Sensitivity in Cancer Cells August 11, 2025Contributors : Anat Galis-Vivante ; Nehal Dwivedi ; Michael Sheetz ; Guy NirSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRigidity sensing enables cells to respond to extracellular matrix stiffness and governs survival and apoptotic decisions. Tropomyosin 2.1 (Tpm2.1), a key actin-binding protein, is frequently downre […]
- GSE303643 Pancreatic cells are resistant to KRASQ61L expression due to hyperactivation of ERK/MAPK signaling and induction of apoptosis August 11, 2025Contributors : Guy A Hobbs ; Rachel A Burge ; Silvia VaenaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe RAS family of small GTPases is among the most frequently mutated gene families in human cancer. In pancreatic ductal adenocarcinoma (PDAC), ~95% of cases harbor an activating KRAS mutation, primarily at codon 12 […]
- GSE304652 Zingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of Sat1 and Gpx4 expression August 11, 2025Contributors : Hao Li ; Fangming Cao ; Dian Liu ; Lin TaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusZingerone, a component of dried ginger, has known anti-ulcer and bone growth-promoting effects, but its impact on postmenopausal osteoporosis (PO) is unclear. This study investigates the therapeutic potential and und […]
- GSE304284 Expression of TKS4 isoforms, TKS5 isoforms, WIP, WASL, CR16, and TTP in MCF7 cell line, with TKS4 knockout, TKS4L isoform overespression and TKS4b isoform overespression August 11, 2025Contributor : Serhii KropyvkoSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe expression of multiple TKS4 isoforms, TKS5 isoforms, WIP, WASL, CR16, and TTP was assessed in MCF7 cell line, with TKS4 knockout, TKS4L isoform overespression and TKS4b isoform overespression
- GSE304690 PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy [MG_HG] August 11, 2025Contributors : Jian Zhao ; Junbiao Zhang ; Yanli Liu ; Lili Wang ; Chunxi Huang ; Wei Chi ; Meixia AnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn diabetic retinopathy (DR), hyperglycemia induces retinal pigment epithelium (RPE) cell senescence via downregulation of PDZK1. PDZK1 overexpression counteracts senescenc […]
- GSE304918 Thyroid Hormone Promotes Fetal Neurogenesis [scRNA-Seq] August 11, 2025Contributors : Federico Salas-Lucia ; Sergio Escamilla ; Amanda Charest ; Hanzi Jiang ; Randy Stout ; Antonio C BiancoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMaternal low thyroxine (T4) serum levels during the first trimester of pregnancy correlate with cerebral cortex volume and mental development of the progen […]
- GSE305057 Deep Mutational Scanning Reveals EGFR Mutations Conferring Resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945 August 11, 2025Contributors : Yueyang Wang ; Yuan Hao ; Michela Ranieri ; Tigran M Abramyan ; Lev Tsidilkovski ; Michelle Hollenberg ; Alfonso Lopez ; Xavier Moore ; Fiona Sherman ; Jiehui Deng ; Hayk Saribekyan ; Garegin Papoian ; Kwok-kin Wong ; Elaine Shum ; John T PoirierSeries Type : OtherOrganism : Mus musculusFourth-generation EGFR tyrosine kinase are in development […]
- GSE305186 Thyroid Hormone Promotes Fetal Neurogenesis [bulk RNA-Seq] August 11, 2025Contributors : Federico Salas-Lucia ; Sergio Escamilla ; Amanda Charest ; Hanzi Jiang ; Randy Stout ; Antonio C BiancoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMaternal low thyroxine (T4) serum levels during the first trimester of pregnancy correlate with cerebral cortex volume and mental development of the progen […]