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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE271937 DNA language models reveal the architecture of nucleotide dependencies in genomes July 19, 2025Contributors : Pedro Tomaz da Silva ; Alexander Karollus ; Johannes Hingerl ; Gihanna Galindez ; Nils Wagner ; Xavier Hernandez-Alias ; Danny Incarnato ; Julien GagneurSeries Type : OtherOrganism : Escherichia coliWhile the genome is composed of individual nucleotides, functional elements such as cis-regulatory elements and structural interactions are formed […]
- GSE290637 RNA-seq of aging mouse skin treated with red light, compared to untreated controls July 19, 2025Contributors : Haocai Chang ; Qi Shen ; Jing TongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUsing an aging mouse model (C57BL/6, 18-20 months), we applied red light irradiation (8 J/cm², once daily for 28 consecutive days) to investigate its potential in alleviating skin degeneration. Gene expression changes were a […]
- GSE274483 Transcriptomic heterogeneity of quiescent neural stem cells underlies distinct reactivation routes and potential upon Notch signaling blockade July 19, 2025Contributors : David Morizet ; Isabelle Foucher ; Ilona Mignerey ; Alessandro Alunni ; Laure Bally-CuifSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioAdult Neural Stem Cells (NSCs) are glial cells that remain mostly quiescent but periodically activate to support neurogenesis throughout life in many species. It has progr […]
- GSE299206 BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells July 19, 2025Contributors : Jieyu Guo ; Jinghua MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe relationship between enhancer region chromatin accessibility of the Leukemia Inhibitory Factor Receptor (Lifr) gene and the regulation of self-renewal in mouse embryonic stem cells (mESCs)remains poorly understood. In this study, we […]
- GSE290732 Deep tissue profiling of Populus stem at single nucleus level reveals uncharacterized cell types and cell-specific gene regulatory networks July 19, 2025Contributors : Henry W. Schmidt ; Daniel Conde ; Wendell J. Pereira ; Paolo Triozzi ; Kelly M. Balmant ; Christopher Dervinis ; Matias KirstSeries Type : Expression profiling by high throughput sequencingOrganism : Populus trichocarpaThe vascular cambium is responsible for the production of secondary xylem, which comprises the most abundant form of biomass o […]
- GSE303062 SPR-5; MET-2 maternal reprogramming cooperates with the Dream and MEC Complexes to regulate developmental cell fates July 19, 2025Contributors : Sindy Chavez ; Jazmin Dozier ; Saahj Gosrani ; Sandra Nguyen ; Jovan Brockett ; Sarah Blancher ; Sydney Morgan-Benitez ; Juan Rodriguez ; Onur Birol ; Monica Reeves ; Karen Schmeichel ; David Katz ; Brandon CarpenterSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansProper regulation of tissue-spec […]
- GSE299411 BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells [ChIP-seq] July 19, 2025Contributors : Jieyu Guo ; Jinghua MaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe relationship between enhancer region chromatin accessibility of the Leukemia Inhibitory Factor Receptor (Lifr) gene and the regulation of self-renewal in mouse embryonic stem cells (mESCs)remains poorly understood. In […]
- GSE302517 The IFN-I-DUSP2-NFAT axis Limits Tumor Remodeling and Immunotherapy Response in Lung Cancer July 19, 2025Contributors : Jinghui Wang ; Dan Lu ; Mengfan Guo ; Xin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusType I interferons (IFN-I) exert context-dependent effects in tumor microenvironment (TME), but their role in shaping immunotherapy response remains unclear. Here, we performed single-cell RNA sequencing of lung […]
- GSE302492 LncRNA transcriptome profiling of three sheep skeletal muscles July 19, 2025Contributors : Xuesong Shan ; Dandan Tan ; Yang Chen ; Huaizhi JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesThis study uses skeletal muscles from different parts of sheep as research materials to explore and compare the muscle fiber types and their characteristics in various parts of the sheep's skeletal musc […]
- GSE302548 Developing a Prognostic Stratification Model Based on Glutathione Metabolism in Thyroid Cancer and Validating RRM2’s Tumor‑Promoting Role July 19, 2025Contributors : Wei Ao ; Teng-Hong Liu ; De-Tao Yin ; Wen-Xin ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlutathione (GSH), the most abundant antioxidant in cells, acts as free radical scavenger and detoxifying agent. Elevation of GSH metabolism protects tumor from damage of oxidant and even promotes tumor progr […]
- GSE302525 T-bet and Runx3 orchestrate effector CD8 T cell differentiation and lineage fidelity through cooperative and distinct chromatin regulatory mechanisms July 19, 2025Contributors : Qiang Shan ; Xiaoyu LinSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusEffector CD8⁺T cells must rapidly acquire cytotoxic functions while maintaining lineage fidelity and suppressing alternative fates. T-bet and Runx3 are key transcriptio […]
- GSE302563 Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling July 19, 2025Contributors : Ziyu Chen ; Zhi Yao ; Mengfan Wu ; Yuluan Wu ; Jianlin Zhang ; Lixiang Xue ; Deli WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSecondary lymphedema, a progressive disorder characterized by pathological fibroadipose tissue accumulation, is a common problem after cancer treatment and orthopedic surge […]
- GSE302616 Comparative transcriptome profiles of first-stage larvae and adult female Dracunculus medinensis (Guinea worm) July 19, 2025Contributors : Hassan Hakimi ; Sabina Beilstein ; Michael J Yabsley ; Christopher A Cleveland ; Lucienne Tritten ; Guilherme G VerocaiSeries Type : Expression profiling by high throughput sequencingOrganism : Dracunculus medinensisDracunculus medinensis, also called the Guinea worm, is a nematode that causes dracunculiasis, a debilitating neglected tropical […]
- GSE303050 Synergistic Effects of Red Light and Direct Current Electric Fields on Neurite Growth in 3D Neural Cell Cultures July 19, 2025Contributors : Yu-Chiu Kao ; Her-Bang Huang ; Chau-Hwang LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBoth red-light illumination and direct-current electric fields (dcEFs) have independently been shown to promote neurite outgrowth in two-dimensional (2D) neural cell cultures. However, their combined effects in a […]
- GSE259217 Metabolic regulation of host defense against influenza virus infection through sensing oxaloacetate July 19, 2025Contributors : Shouheng Jin ; Xing HeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMetabolic pathways instructing the cellular fate and function, however, the exact roles of metabolites in host immune responses remain undefined. Using unbiased metabolomics and pharmacological inhibition analysis, we repo […]