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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299800 m5C-MeRIP-seq of HHL5 cells June 20, 2025Series Type : OtherOrganism : Homo sapiensWe discovered the YBX1 in the lipid-induced particles assembled by DDX49, YBX1 is an m5C reader and constitutively associates with Timp2 mRNA in hepatocytes, we examined whether their association was dependent on the m5C modification of Timp2 mRNA, then we performed m5C-MeRIP-seq.
- GSE206726 Epigenetic reprogramming of the mesenchymal state by SUV39H1/H2 [ChIP-Seq] June 20, 2025Contributors : Junichi Hanai ; Noriko Ide ; Alex O Gulka ; Jingyu Zhang ; Gracia Bonilla ; Ruslan Sadreyev ; Toshi Shioda ; Mo MotamediSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEmergence of chemotherapy resistance is a major clinical challenge resulting in large number of deaths yearly. One mechanism […]
- GSE206475 The methylation rate of the promoter and first exon of RELB in esophageal squamous cell carcinoma and para-carcinoma tissues June 20, 2025Contributors : Lijuan Gao ; Yongshun chenSeries Type : Methylation profiling by high throughput sequencingOrganism : unidentifiedTo illustrate the molecular mechanism of the overexpression of RELB in esophageal squamous cell carcinoma compared with para-carcinoma tissuesWe then calculated bismark analysis using data obtained from bisulfite target sequencing […]
- GSE266983 m6A-modified RNAs in human amniotic epithelial stem cells derived-insulin-producing cells: Wild type vs. overexpressed METTL3 plasmid transfected June 20, 2025Contributors : Yunfei Luo ; Jianping LiuSeries Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Homo sapiensm6A-modified RNAs expression profiles of human amniotic epithelial stem cells differentiation into insulin-producing cells and comparing Wild type with overexpressed METTL3 plasmid transfected.Goal was to determine the […]
- GSE206728 Epigenetic reprogramming of the mesenchymal state by SUV39H1/H2 June 20, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE273752 Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia a June 20, 2025Contributors : Hannah D Mason ; Yvonne L Latour ; Christopher T Boughter ; Kory R Johnson ; Dragan Maric ; Cayce E Dorrier ; Vivian A Guedes ; Chen Lai ; Patrick C Duncker ; Alexis M Johnson ; Monica Manglani ; Jessica M Gill ; Daniel P Perl ; Martin Meier-Schellersheim ; Dorian B McGavernSeries Type : Expression profiling by high throughput sequencingOrgani […]
- GSE271050 Transcriptome profiling of developing testes in the horse [RNA-seq] June 20, 2025Contributors : Paula Navarrete-López ; Cristina García-Merino ; Eva Pericuesta ; Alfonso Gutiérrez-AdánSeries Type : Expression profiling by high throughput sequencingOrganism : Equus caballusThe mammalian testis is a highly heterogeneous tissue with a vast array of functional and regulatory RNA molecules that participate in the timely control of the spermat […]
- GSE294038 SNU449 and SNU449 sorafenib-resistant cell line gene expression profiling June 20, 2025Contributors : Jaejin Song ; Sujin ChoiSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe used microarrays to investigate transcriptomic changes between parental SNU449 and sorafenib-resistant SNU449 cells under various shRNA knockdown conditions.Samples included control, sorafenib-resistant, Ad-shHSP27, Ad-shTGFβ1, Ad-shHSP27-shTGFβ1 and A […]
- GSE293292 Viable semi-cloned mice derived from androgenetic haploid stem cells lacking DNA methylation [bisulfite-Seq] June 20, 2025Contributors : Zhenyu Shao ; Yin WangSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusAmong all mammalian cell types, sperm exhibit the highest level of DNA methylation, with approximately 70–80% of CpG sites being methylated. The role of this paternal hypermethylation in embryonic developmental competence, aside from t […]
- GSE297557 Age-associated Tissue Organization Shifts Retinal Pigmented Epithelium Actomyosin Plasticity in Phagocytosis June 20, 2025Contributors : Teodora Piskova ; Aleksandra N Kozyrina ; Giedrė Astrauskaitė ; Mohamed Elsafi Mabrouk ; Sebastian Schepl ; Stacy Lok Sze Yam ; Ragul Ravithas ; Wolfgang Wagner ; Massimo Vassalli ; Jacopo Di RussoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMechanical homeostasis in healthy tissues relies on a dynamic […]
- GSE296909 5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma June 20, 2025Contributors : Yuanying Feng ; Hua GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitor (TKI) remains a critical clinical challenge in EGFR mutant lung adenocarcinoma (LUAD). Therefore, it is urgent to explore personalized treatment strategie […]
- GSE299290 Targeted pseudouridylation identifies a novel Ψ-Ψ codon-anticodon pairing in nonsense suppression and translational recoding June 20, 2025Contributors : Yi-Tao Yu ; Yi PanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Saccharomyces cerevisiaePseudouridine (Ψ) is known for decades, but its flexibility in base-pairing remains unclear. This study engineers artificial box H/ACA guide RNAs to direct pseudouridylation at the uridine of a premature termination codo […]
- GSE299729 Overexpression of NPY leads to a progressive, cutaneous inflammatory fibrotic response in mouse skin. June 20, 2025Contributors : Dawson D Alex ; Harris L MelissaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuropeptide Y (NPY) is a pleiotropic peptide produced in the central nervous system and peripheral organs and is upregulated in some human skin conditions like atopic dermatitis. We reported previously that a knock-in mouse w […]
- GSE299784 GATA Transcription Factors Coordinate Developmental Progression in the Arabidopsis Root June 20, 2025Contributors : Tom Denyer ; Pavel Solansky ; Francesco de Martino ; Efthymia Symeonidi ; Arvid Herrmann ; Valentin Brösamle ; Marja TimmermansSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaFor proper organ development, cell proliferation and cellular differentiation must balance in a tightly regul […]
- GSE273757 Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia c June 20, 2025Contributors : Hannah D Mason ; Yvonne L Latour ; Christopher T Boughter ; Kory R Johnson ; Dragan Maric ; Cayce E Dorrier ; Vivian A Guedes ; Chen Lai ; Patrick C Duncker ; Alexis M Johnson ; Monica Manglani ; Jessica M Gill ; Daniel P Perl ; Martin Meier-Schellersheim ; Dorian B McGavernSeries Type : Expression profiling by high throughput sequencingOrgani […]